New diterpenoids from the stems of Euphorbia antiquorum growing in Vietnam

Journal article

Authors/Editors

NAKORN NIAMNONT

Strategic Research Themes

Publication Details

Author list: Thanh-Nha Tran, Jirapast Sichaem, Van-Kieu Nguyen, Huu-Hung Nguyen, Truong-Tam Cao, Thi-Phuong Nguyen, Van-Giau Vo, Nakorn Niamnont, Ngoc-Hong Nguyen & Thuc-Huy Duong

Publisher: Taylor and Francis Group

Publication year: 2022

Volume number: 36

Issue number: 2

Start page: 523

End page: 530

Number of pages: 8

ISSN: 1478-6419

eISSN: 1478-6427

URL: https://www.tandfonline.com/doi/full/10.1080/14786419.2020.1789634

Languages: English-United States (EN-US)

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Abstract

Phytochemical analysis of Euphorbia antiquorum stem extracts afforded two new ent-atisane compounds, ent-3a-acetoxy16b,17,18-trihydroxyatisane (1) and ent-3a,14,16b,17-tetrahydroxyatisane (2) together with three known compounds, 20-deoxy-16- hydroxyingenol (3), ent-14[S],16a,17-trihydroxyatisan-3-one (4), and agallochaol C (5). Their structures were elucidated by spectroscopic data analysis and comparison with published NMR data. Compounds 1–5 were evaluated for a-glucosidase inhibition and cytotoxicity. Compounds 1, 4, and 5 revealed significant inhibitory activity against a-glucosidase with the IC50 values of 119.9, 135.5, and 134.3 mM, respectively. None showed activity in cytotoxicity assay

Keywords

ent-atisane diterpenoid, Euphorbia antiquorum L, Euphorbiaceae, α-glucosidase inhibition