Hexane Extract of Seaweed Caulerpa lentillifera Inhibits Cell Proliferation and Induces Apoptosis of Human Glioblastoma Cells

Journal article

Authors/Editors

Strategic Research Themes

Publication Details

Author list: Varitta Tanawoot;Pornpun Vivithanaporn; Tanapan Siangcham;Krai Meemon;Nakorn Niamnont;Prasert Sobhon;Montakan Tamtin, Kant Sangpairoj;

Publication year: 2021

Volume number: 26

Issue number: 2

Start page: 128

End page: 137

Number of pages: 10

ISSN: 2586-9000

URL: https://ph02.tci-thaijo.org/index.php/SciTechAsia/article/view/219342

Abstract

Glioblastoma is one the most aggressive types of brain cancers resistant to conventional anti-neoplastic drugs. Marine seaweeds possess valuable bioactive compounds for disease prevention and therapy, including for a number of cancers. Caulerpa lentillifera is a tropical marine seaweed containing various minerals and bioactive ingredients. This study demonstrated the activity of C. lentillifera hexane extract (CLHE) against A172 human glioblastoma cells. The extract exerted growth-inhibitory effects by inhibiting cell proliferation and inducing apoptosis. CLHE also induced ROS accumulation and altered mitochondrial membrane potential in A172 cells. Taken together, CLHE might be a potential anticancer agent for use against glioblastoma.

Keywords

Glioblastoma, Proliferation