A smartphone-assisted hybrid sensor for simultaneous potentiometric and distance-based detection of electrolytes

บทความในวารสาร

ผู้เขียน/บรรณาธิการ

กลุ่มสาขาการวิจัยเชิงกลยุทธ์

รายละเอียดสำหรับงานพิมพ์

รายชื่อผู้แต่ง: Phoonsawat, Kamonchanok; Agir, Ismail; Dungchai, Wijitar; Ozer, Tugba; Henry, Charles S.;

ผู้เผยแพร่: Elsevier

ปีที่เผยแพร่ (ค.ศ.): 2022

วารสาร: Analytica Chimica Acta (0003-2670)

Volume number: 1226

หน้าแรก: 340245

นอก: 0003-2670

URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85137310743&doi=10.1016%2fj.aca.2022.340245&partnerID=40&md5=162c3d1f67606bb9119227ed0de5180e

ภาษา: English-Great Britain (EN-GB)

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บทคัดย่อ

At home electrolyte analysis is of growing interest due to the importance for early diagnosis for various diseases. This work presents the first device that integrates a potentiometric ion-selective electrode (ISE) with distance-based colorimetric detection for the simultaneous analysis of K+ and Cl- ions at the point of care (POC). This hybrid sensing device was designed in a two-dimensional configuration using a plastic transparency sheet containing a stencil printed K+-ISE and a paper substrate for distance-based colorimetric detection of Cl-. K+ quantification was performed using a low-cost (<$25) lab-made Wi-Fi supported potentiometer with a custom smartphone application while Cl- ions were quantified with an instrument-free distance-based paper analytical device (dPAD). The total analysis time is 5 min once the sample is added. The K+-ISE showed a sensitivity of 55.89 ± 2.52 mV/decade from 0.1 to 100 mM with a limit of detection (LOD) of 0.01 mM. The linear working range for Cl- detection was 0.5-50 mM whereas the LOD was 0.16 ± 0.05 mM. The proof-of-concept application of the sensing hybrid device was demonstrated in human urine and artificial sweat samples containing K+ and Cl- ions at physiologically relevant ranges. The recoveries were found to be 88-108% for K+ and 90-104% for Cl-, showing the potential use of the proposed device for low-cost routine analysis of biological samples at POC. Copyright © 2022 Elsevier B.V. All rights reserved.

คำสำคัญ

colorimetric detection, Distance-based paper device, Potassium, Potentiometric ion-selective electrode