Phytochemical screening, quantitative analysis of cyanidin-3-O-glucoside content, and anticancer activity of novel rice bran (Tubtim Chumphae rice)

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Publication Details

Author list: Rungruang, Rittipun; Peasura, Napassorn; Kaisangsri, Nattapon;

Publisher: Medknow Publications

Publication year: 2022

Journal acronym: J Adv Pharm Technol Res .

Volume number: 13

Issue number: 4

Start page: 312

End page: 316

Number of pages: 5

ISSN: 2231-4040

eISSN: 0976-2094

URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85140716015&doi=10.4103%2fjaptr.japtr_458_22&partnerID=40&md5=74377f84a4a587420fd00923c5892b9f

Languages: English-Great Britain (EN-GB)

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Abstract

The objective of this research was to explore the phytochemicals in Tubtim Chumphae rice bran and determine their potential antioxidant and anticancer activities. The rice bran extract contained total phenolics, flavonoids, and anthocyanins as the major compounds. In addition, it exhibited the highest DPPH•, followed by ABTS•+, and FRAP radical scavenging activity. Moreover, the cytotoxic effect of the extract on Hep G2, SW620, KATO-III, BT474, and ChaGo-K-1 cancer cell lines was investigated; the obtained IC50 values were 144.6 ± 0.39, 116.9 ± 0.68, 99.6 ± 0.10, 94.4 ± 0.33, and 25.6 ± 0.45 μg/mL, respectively. Overall, the abovementioned results suggest that rice bran extract has potent anticancer activity owing to the induction of cell death in cancer cell lines. © 2022 Journal of Advanced Pharmaceutical Technology & Research.

Keywords

rice bran extract (Tubtim Chumphae rice)