Polarity and viscosity-sensitive fluorescence probes for lipid droplet imaging in cancer cells

บทความในวารสาร

ผู้เขียน/บรรณาธิการ

กลุ่มสาขาการวิจัยเชิงกลยุทธ์

รายละเอียดสำหรับงานพิมพ์

รายชื่อผู้แต่ง: Duangkamol, Chuthamat; Muangsopa, Prapassara; Rattanopas, Sopita; Wongsuwan, Pornpimol; Khrootkaew, Tunyawat; Chueakwon, Piyasiri; Niamnont, Nakorn; Chansaenpak, Kantapat; Kamkaew, Anyanee;

ผู้เผยแพร่: Elsevier

ปีที่เผยแพร่ (ค.ศ.): 2023

Volume number: 216

นอก: 0143-7208

eISSN: 1873-3743

URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85158896351&doi=10.1016%2fj.dyepig.2023.111365&partnerID=40&md5=d17605955fe69bf99da5d26da2447182

ภาษา: English-Great Britain (EN-GB)

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บทคัดย่อ

Fluorescent probes sensitive to microenvironments have constantly been attractive, due to their significant benefits in monitoring changes in the pathophysiological microenvironment and their use in the early detection of associated disorders. In this work, we explored three new molecular rotors that could be potential candidates for detecting lipid droplets (LDs) in cancer cells based on coumarin derivatives connected with electron-donating polycyclic units including, tetraphenylethylene (LD-TPE), pyrene (LD-PYR), and 4,5-diphenylimidazole (LD-DIP). Gratifyingly, LD-PYR showed exceptional polarity and viscosity sensitivity and demonstrated bright fluorescence in highly viscous environments due to the suppression of the twisted intramolecular charge transfer (TICT) phenomenon and intramolecular rotation. Moreover, microenvironment-guided specific LD bioimaging by LD-PYR exhibited a reasonable ability to distinguish between cancer and noncancer cells. These data suggested that LD-PYR has interesting clinical diagnostic and microenvironment-related biological applications. © 2023 Elsevier Ltd

คำสำคัญ

Cancer cells imaging, Fluorescence imaging, Lipid droplets detection, Twisted intramolecular charge transfer, Viscosity-sensitive probe