A novel fluorescent sensor based on triphenylamine-hydrazone for Cu2+ ion detection

An elevated concentration of Cu2+ ions has been shown to be caused by the onset of many human disorders, including prion disease, Alzheimer's disease, Wilson's disease, and Menkes disease. Furthermore, the presence of Cu2+ ions contributes to environmental pollution. The primary objective of this study is to concentrate on the development and production of a novel fluorescence sensor for the purpose of detecting Cu2+ ions. The fluorescence sensor used in our study is denoted as TPA-TF, which has a triphenylamine moiety connected to a thiophene unit serving as the donor group. The receptor group consists of furan-linked hydrazone. The TPATF compound, when dissolved in an aqueous solution consisting of 100% DMSO/Tris (in a volumetric ratio of 1:99), has the ability to rapidly detect the presence of Cu2+ ions in less than one minute. The limit of detection was determined to be 6 μM. The linear range spanned from 0 to 700 μM. Additionally, the TPA-TF was able to identify the presence of Cu2+ ions inside viable cells. Therefore, the TPA-TF demonstrates significant efficacy as a fluorescence sensor specifically designed for the detection of Cu2+ ions.