Dynamic Model of Andrographolide Therapy for COVID-19

Andrographis paniculate extract (APE) has been used as a Thailand traditional medicine owing to andrographolide which is effective for the viral clearance and prevention of disease progression. Several viral infections have been treated with APE, including SARS-CoV-2. The recommended dosage is 180 mg three times a day. We constructed a mathematical viral dynamic model of the SARS-CoV-2 model with andrographolide therapy by different doses. The pharmacokinetic/pharmacodynamic (PK/PD) model reduces the duration of viral clearance with a dose of 60 mg per day. Moreover, APE improved the therapeutic efficacy of COVID-19 therapy.