Fluoride containing strontium substituted calcium mesoporous bioactive glass nanoparticles

Monodispersed spherical fluoride containing strontium substituted calcium mesoporous bioactive glass nanoparticles (xSr-yF-MBGNs) with a hydrodynamic diameter range from 170 to 200 nm were successfully prepared using a microemulsion assisted sol-gel used a basic condition. A cationic surfactant (CTAB) was used to generate the mesopore structure pattern, a pore diameter of 8-10 nm. The particles were stable in aqueous solution as Zeta potential increased from -33 mV to -58 mV in the particle doping with F. F and Sr were incorporated into the MBGNs without altering physicochemical properties of the particles including size, morphology, pore size, and amorphous structure. In addition, xSr-yF-MBGNs at concentrations up to 1 mg/mL have no toxic effect on the hMSCs in vitro.