A novel triphenylamine-furan hydrazone-based sensing of Cu2+ ions and imaging in cancer cells
บทความในวารสาร
ผู้เขียน/บรรณาธิการ
กลุ่มสาขาการวิจัยเชิงกลยุทธ์
รายละเอียดสำหรับงานพิมพ์
รายชื่อผู้แต่ง: Mayurachayakul P., Chantarasriwong O., Kamkaew A., Sukwattanasinitt M., Niamnont N.
ผู้เผยแพร่: Elsevier
ปีที่เผยแพร่ (ค.ศ.): 2024
วารสาร: Journal of Molecular Structure (0022-2860)
Volume number: 1310
หน้าแรก: 138298
นอก: 0022-2860
eISSN: 1872-8014
ภาษา: English-Great Britain (EN-GB)
บทคัดย่อ
A novel fluorescent probe (TPA-TF) was designed and synthesized, incorporating triphenylamine-thiophene moieties coupled with furan and a hydrazone. First, the TPA-TF can be used as a sensor to detect Cu2+ in the environment/biosystem through an effective fluorescence quenching due to chelation-enhanced fluorescence quenching (CHEQ) and inhibiting the photoinduced electron transfer (PET) process. Various fluorescence spectra and density functional theory (DFT) computations were used to clarify the TPA-TF to Cu2+ detection characteristics. The Cu2+ sensor TPA-TF exhibited a fast response time of one minute. In this study, the linear range concentration for the Cu2+ ion detection was 0–1000 μM, with a broad pH working range (pH 2.7–7.4), and the detection limit of the sensor was 6.08 μM. With its broad applicability, the TPA-TF sensor was successfully used to detect and photograph Cu2+ in live cells, demonstrating its considerable potential for applications in biological imaging. © 2024 Elsevier B.V.
คำสำคัญ
Cu(II), Triphenylamine
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