Mathematical Model of SARS-CoV-2 infection with Andrographolide Therapy

Other

Authors/Editors

Strategic Research Themes

Publication Details

Author list: Yarnvitayalert P.; Saleewong T.

Publisher: Association for Computing Machinery

Publication year: 2024

Start page: 105

End page: 108

Number of pages: 4

ISBN: 979-840071728-4

URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85203367504&doi=10.1145%2f3670085.3670102&partnerID=40&md5=43d9a184b54f1bb983f4097f69153d0a

Languages: English-Great Britain (EN-GB)

View on publisher site

Abstract

Andrographis paniculata extract (APE), containing andrographolide, has long been used in Thai traditional medicine for its antiviral properties, including against SARS-CoV-2. The recommended dose in Thailand is 180 milligrams three times daily. We developed a mathematical model incorporating the pharmacokinetic/pharmacodynamic (PK/PD) profile of andrographolide therapy to predict viral dynamics in four COVID-19 patients. APE was found to enhance the efficacy of COVID-19 treatment. Despite similar infection behavior, there were differences in the quality of the virus peak between treated and untreated patients. © 2024 Owner/Author.

Keywords

pharmacodynamic, pharmacokinetic, viral dynamic model