MethyCancer: The database of human DNA methylation and cancer

Journal article

Authors/Editors

KANTHIDA KUSONMANO

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Publication Details

Author list: He X., Chang S., Zhang J., Zhao Q., Xiang H., Kusonmano K., Yang L., Sun Z.S., Yang H., Wang J.

Publisher: Oxford University Press

Publication year: 2008

Journal: Nucleic Acids Research (0305-1048)

Volume number: 36

Issue number: SUPPL. 1

Start page: D836

End page: D841

ISSN: 0305-1048

eISSN: 1362-4962

URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-38549129812&doi=10.1093%2fnar%2fgkm730&partnerID=40&md5=c7deac9c88a6aa485cde34b8c9ca714a

Languages: English-Great Britain (EN-GB)

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Abstract

Cancer is ranked as one of the top killers in all human diseases and continues to have a devastating effect on the population around the globe. Current research efforts are aiming to accelerate our understanding of the molecular basis of cancer and develop effective means for cancer diagnostics, treatment and prognosis. An altered pattern of epigenetic modifications, most importantly DNA methylation events, plays a critical role in tumorigenesis through regulating oncogene activation, tumor suppressor gene silencing and chromosomal instability. To study interplay of DNA methylation, gene expression and cancer, we developed a publicly accessible database for human DNA Methylation and Cancer (MethyCancer, http://methycancer.genomics.org. cn). MethyCancer hosts both highly integrated data of DNA methylation, cancer-related gene, mutation and cancer information from public resources, and the CpG Island (CGI) clones derived from our large-scale sequencing. Interconnections between different data types were analyzed and presented. Furthermore, a powerful search tool is developed to provide user-friendly access to all the data and data connections. A graphical MethyView shows DNA methylation in context of genomics and genetics data facilitating the research in cancer to understand genetic and epigenetic mechanisms that make dramatic changes in gene expression of tumor cells. ฉ 2007 The Author(s).

Keywords