Anti HSV-1 activity of sulphoquinovosyl diacylglycerol isolated from spirulina platensis

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Author list: Chirasuwan N., Chaiklahan R., Kittakoop P., Chanasattru W., Ruengjitchatchawalya M., Tanticharoen M., Bunnag B.

Publication year: 2009

Journal: ScienceAsia (1513-1874)

Volume number: 35

Issue number: 2

Start page: 137

End page: 141

Number of pages: 5

ISSN: 1513-1874

URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-68649116495&doi=10.2306%2fscienceasial513-1874.2009.35.137&partnerID=40&md5=7822477641180faf09c88e1470f2ed3c

Languages: English-Great Britain (EN-GB)

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Abstract

Herpes simplex virus type 1 (HSV-1) causes a variety of infections in humans and can be found in many countries worldwide. Although the antiherpes drug, acyclovir, has been used very successfully, an acyclovir-resistant strain of HSV has recently been found in patients and drug toxicity has been reported with increasing use of it. As a potential alternative, it has been found that both a water soluble and a Iipid extract of the microalga Spirulina platensis exhibit antiviral activity (HSV-1) in Vero cells. In this study, bioassay guided fractionation of a Iipid extract from S. platensis led to the identification of sulphoquinovosyl diacylglycerol as the active antiviral agent. The chemical structure of this compound was confirmed by NMR and LC-mass spectroscopic analyses. Results from the study showed that the compound exhibited a remarkable activity against HSV-1 with an IC50 value of 6.8 μg/ml, which was comparable to that of acyclovir (1.5 μg/ml).

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