Prediction of non-coding RNA and their targets in Spirulina platensis genome

Conference proceedings article

ผู้เขียน/บรรณาธิการ

กลุ่มสาขาการวิจัยเชิงกลยุทธ์

ไม่พบข้อมูลที่เกี่ยวข้อง

รายละเอียดสำหรับงานพิมพ์

รายชื่อผู้แต่ง: Srisuk T., Pornputtapong N., Cheevadhanarak S., Thammarongtham C.

ผู้เผยแพร่: Springer Verlag (Germany): Computer Proceedings

ปีที่เผยแพร่ (ค.ศ.): 2010

Volume number: 115 CCIS

หน้าแรก: 106

หน้าสุดท้าย: 117

จำนวนหน้า: 12

ISBN: 3642167497; 9783642167492

นอก: 1865-0929

URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-78649515630&doi=10.1007%2f978-3-642-16750-8_10&partnerID=40&md5=8d752b92620375ea198e6416665900e9

ภาษา: English-Great Britain (EN-GB)

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บทคัดย่อ

Non-coding RNAs (ncRNAs), transcripts that have function without being translated to protein, have a number of roles in the cell including important regulatory roles. Efforts to identify the whole set of ncRNAs and then to elucidate their functions would gain better biological understanding. Although ncRNA is another type of genome constituent, most of the genes for ncRNA are overlooked by standard genome annotation of genome sequencing projects. This also happens in Spirulina platensis genome sequencing project. It is because gene finding tools generally are able to identify only protein-coding genes but not non-protein-coding ones. In this study, S. platensis ncRNAs were detected by comparative genomics approach using computational tools, together with RNA secondary structure prediction. It was found that more than 100 predicted ncRNA loci matched with known ncRNAs for example cobalamin riboswitch, RNaseP, Signal Recognition Particle RNA, Group II intron RNA and Yfr1. It has been reported that Yfr1 has been found in most cyanobacterial genomes sequenced. The result showed that more than 70 putative loci were similar to Group II intron RNAs. In addition, approximately 100 predicted ncRNA loci were not matched with any known ncRNAs. The predicted targets for some putative ncRNAs are also proposed. ฉ 2010 Springer-Verlag Berlin Heidelberg.

คำสำคัญ

non-coding RNA prediction, non-coding RNA target prediction