Genome-based screening for drug targets identification: Application to typhoid fever
Conference proceedings article
Authors/Editors
Strategic Research Themes
No matching items found.
Publication Details
Author list: Juntrapirom A., Kalapanulak S., Saithong T.
Publisher: Springer Verlag (Germany): Computer Proceedings
Publication year: 2010
Volume number: 115 CCIS
Start page: 217
End page: 225
Number of pages: 9
ISBN: 3642167497; 9783642167492
ISSN: 1865-0929
Languages: English-Great Britain (EN-GB)
View in Web of Science | View on publisher site | View citing articles in Web of Science
Abstract
Salmonella enterica serovar Typhi CT18 (S. Typhi) is the causative agent of typhoid fever in human beings. Currently, most of the drugs used to treat this sickness have adverse side-effects. Moreover, drug-resistant strains are emerging as a serious threat for the disease. Therefore, the most effective drug targets are urgently demanded for the development of new faster-acting antibacterial agents. In this paper, a published method for drug targets identification in Mycobacterium tuberculosis metabolismby Kalapanulak was applied to typhoid fever. The whole genome of S. Typhi was investigated and 282 genes were proposed as new drug targets. Interestingly, 34 drug-affected and essential genes from the three current antibiotics are all found in our proposed drug targets. ฉ 2010 Springer-Verlag Berlin Heidelberg.
Keywords
drug targets, genome-scale, pathogenic bacteria, Salmonella Typhi, Typhoid Fever
Contact Information