Cellulose acetate electrospun fiber mats for controlled release of silymarin

Conference proceedings article

ผู้เขียน/บรรณาธิการ

กลุ่มสาขาการวิจัยเชิงกลยุทธ์

ไม่พบข้อมูลที่เกี่ยวข้อง

รายละเอียดสำหรับงานพิมพ์

รายชื่อผู้แต่ง: Phiriyawirut M., Phaechamud T.

ผู้เผยแพร่: American Scientific Publishers

ปีที่เผยแพร่ (ค.ศ.): 2012

Volume number: 12

Issue number: 1

หน้าแรก: 793

หน้าสุดท้าย: 799

จำนวนหน้า: 7

นอก: 1533-4880

eISSN: 1533-4899

URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84861588802&doi=10.1166%2fjnn.2012.5343&partnerID=40&md5=298e3831381ad972abeca5a0cc51dbe8

ภาษา: English-Great Britain (EN-GB)

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บทคัดย่อ

In this research, the silymarin-loaded electrospun cellulose acetate (CA) fibers were prepared which containing silymarin in various amounts (i.e., 2.5-20 wt.% based on the weight of CA powder). Incorporation of silymarin in the neat CA solution did not affect the morphology of the resulting fibers, as both the neat and the silymarin-loaded CA fibers were smooth. The average diameters of silymarin-loaded CA fiber ranged between 550-900 nm. No presence of the silymarin aggregates of any kind was observed on the surfaces of these fibers, suggesting that the silymarin was encapsulated well within the fibers. These results were confirmed by lowering the glass transition temperature and the melting temperature of the silymarin-loaded electrospun CA fibers which is determined by DSC technique. The release characteristic of silymarin from the silymarin-loaded CA fiber mats was investigated by the total immersion in the solution of 1/1 phosphate buffer/methanol medium pH 7.4 at 37 ฐC. The silymarin release from the silymarin-loaded electrospun CA fiber mat is monotonously increased to reach the maximum value at 480 min. The maximum amount of silymarin released from these materials increases with the increasing of initial silymarin loading in the spinning CA solutions. Since no aggregation of silymarin was found on the surface of the silymarin-loaded fibers, the release of the silymarin from fiber mats was mainly by the diffusion. Copyright ฉ 2012 American Scientific Publishers.

คำสำคัญ

cellulose acetate, Drug release, Electrospinning, Silymarin