Simple, distance-based measurement for paper analytical devices

Journal article

Authors/Editors

WIJITAR DUNGCHAI

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Publication Details

Author list: Cate D.M., Dungchai W., Cunningham J.C., Volckens J., Henry C.S.

Publisher: Royal Society of Chemistry

Publication year: 2013

Journal: Lab on a Chip (1473-0197)

Volume number: 13

Issue number: 12

Start page: 2397

End page: 2404

Number of pages: 8

ISSN: 1473-0197

eISSN: 1473-0189

URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84878040377&doi=10.1039%2fc3lc50072a&partnerID=40&md5=e930f5bea749549fb42127e760519496

Languages: English-Great Britain (EN-GB)

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Abstract

Paper-based analytical devices (PADs) represent a growing class of elegant, yet inexpensive chemical sensor technologies designed for point-of-use applications. Most PADs, however, still utilize some form of instrumentation such as a camera for quantitative detection. We describe here a simple technique to render PAD measurements more quantitative and straightforward using the distance of colour development as a detection motif. The so-called distance-based detection enables PAD chemistries that are more portable and less resource intensive compared to classical approaches that rely on the use of peripheral equipment for quantitative measurement. We demonstrate the utility and broad applicability of this technique with measurements of glucose, nickel, and glutathione using three different detection chemistries: enzymatic reactions, metal complexation, and nanoparticle aggregation, respectively. The results show excellent quantitative agreement with certified standards in complex sample matrices. This work provides the first demonstration of distance-based PAD detection with broad application as a class of new, inexpensive sensor technologies designed for point-of-use applications. ฉ 2013 The Royal Society of Chemistry.

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