A novel NAD+/MWNTs nanocomposite-based electrochemical biosensor for measuring mevalonic acid
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Publication Details
Author list: Palangsuntikul R., Pakapongpan S., Khownarumit P., Surareungchai W.
Publisher: Trans Tech Publications
Publication year: 2014
Volume number: 605
Start page: 388
End page: 391
Number of pages: 4
ISBN: 9783038350514
ISSN: 1013-9826
eISSN: 1662-9795
Languages: English-Great Britain (EN-GB)
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Abstract
A novel, simple and precise electrochemical biosensor, was developed for measuring mevalonic acid (MA) concentration, which is thought to be a good indicator of HMG-CoA reductase activity. This sensor is based on noncovalent-linking NAD+/MWNTs nanocomposite coated on a screen-printed electrode (SPE). The resulting biosensor exhibited excellent electrocatalytic activity, fast response and good stability to MA. At the NAD+/MWNTs-modified SPE, the current is linear with the concentration of MA being within a concentration range from 18.1 to 145 μM with a limit of detection down to 4.25 μM (S/N = 3), and the sensor exhibited a sensitivity of 92.2 μA/mM. © (2014) Trans Tech Publications.
Keywords
Mevalonic acid, MWNTs
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