Comparative genomic analysis of seven Mycoplasma hyosynoviae strains

บทความในวารสาร

ผู้เขียน/บรรณาธิการ

กลุ่มสาขาการวิจัยเชิงกลยุทธ์

ไม่พบข้อมูลที่เกี่ยวข้อง

รายละเอียดสำหรับงานพิมพ์

รายชื่อผู้แต่ง: Bumgardner E.A., Kittichotirat W., Bumgarner R.E., Lawrence P.K.

ผู้เผยแพร่: Blackwell Publishing Ltd

ปีที่เผยแพร่ (ค.ศ.): 2015

Volume number: 4

Issue number: 2

หน้าแรก: 343

หน้าสุดท้าย: 359

จำนวนหน้า: 17

นอก: 2045-8827

eISSN: 2045-8827

URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84926415709&doi=10.1002%2fmbo3.242&partnerID=40&md5=cb7286cb4b8185816bea8fbef7b6b7ac

ภาษา: English-Great Britain (EN-GB)

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บทคัดย่อ

Infection with Mycoplasma hyosynoviae can result in debilitating arthritis in pigs, particularly those aged 10 weeks or older. Strategies for controlling this pathogen are becoming increasingly important due to the rise in the number of cases of arthritis that have been attributed to infection in recent years. In order to begin to develop interventions to prevent arthritis caused by M. hyosynoviae, more information regarding the specific proteins and potential virulence factors that its genome encodes was needed. However, the genome of this emerging swine pathogen had not been sequenced previously. In this report, we present a comparative analysis of the genomes of seven strains of M. hyosynoviae isolated from different locations in North America during the years 2010 to 2013. We identified several putative virulence factors that may contribute to the ability of this pathogen to adhere to host cells. Additionally, we discovered several prophage genes present within the genomes of three strains that show significant similarity to MAV1, a phage isolated from the related species, M. arthritidis. We also identified CRISPR-Cas and type III restriction and modification systems present in two strains that may contribute to their ability to defend against phage infection. ฉ 2015 The Authors. MicrobiologyOpen published by John Wiley & Sons Ltd.

คำสำคัญ

Adhesin, Antibiotic, CRISPR, Genome, MAA1, Mycoplasma hyosynoviae, OppA, Phage, Resistance