Hydroxyapatite electrodeposition on anodized titanium nanotubes for orthopedic applications
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Author list: Parcharoen Y., Kajitvichyanukul P., Sirivisoot S., Termsuksawad P.
Publisher: Elsevier
Publication year: 2014
Journal: Applied Surface Science (0169-4332)
Volume number: 311
Start page: 54
End page: 61
Number of pages: 8
ISSN: 0169-4332
eISSN: 1873-5584
Languages: English-Great Britain (EN-GB)
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Abstract
Nanotubes modification for orthopedic implants has shown interesting biological performances (such as improving cell adhesion, cell differentiation, and enhancing osseointegration). The purpose of this study is to investigate effect of titanium dioxide (TiO2) nanotube feature on performance of hydroxyapatite-coated titanium (Ti) bone implants. TiO2 nanotubes were prepared by anodization using ammonium fluoride electrolyte (NH 4F) with and without modifiers (PEG400 and Glycerol) at various potential forms, and times. After anodization, the nanotubes were subsequently annealed. TiO2 nanotubes were characterized by scanning electron microscope and X-ray diffractometer. The amorphous to anatase transformation due to annealing was observed. Smooth and highly organized TiO2 nanotubes were found when high viscous electrolyte, NH4F in glycerol, was used. Negative voltage (-4 V) during anodization was confirmed to increase nanotube thickness. Length of the TiO2 nanotubes was significantly increased by times. The TiO2 nanotube was electrodeposited with hydroxyapatite (HA) and its adhesion was estimated by adhesive tape test. The result showed that nanotubes with the tube length of 560 nm showed excellent adhesion. The coated HA were tested for biological test by live/dead cell straining. HA coated on TiO2 nanotubes showed higher cells density, higher live cells, and more spreading of MC3T3-E1 cells than that growing on titanium plate surface. ฉ 2014 Elsevier B.V.
Keywords
Anodic oxidation, Medium modifiers
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