A novel phenylacetylene-indolium fluorophore for detection of cyanide by the naked eye
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Author list: Niamnont N., Promchat A., Siangma C., Pramaulpornsatit C., Sukwattanasinitt M.
Publisher: Royal Society of Chemistry
Publication year: 2015
Journal: RSC Advances (2046-2069)
Volume number: 5
Issue number: 79
Start page: 64763
End page: 64768
Number of pages: 6
ISSN: 2046-2069
eISSN: 2046-2069
Languages: English-Great Britain (EN-GB)
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Abstract
A novel fluorescent turn-on cyanide sensor containing an indolium salt as the selective CN- receptor was synthesized in 2 steps via Sonogashira coupling and Knoevenagel reaction. Compound 2 was developed as a new fluorometric and colorimetric sensor for cyanide with a sensing mechanism through cyanide ion addition to the indolium group. Importantly, the inclusion complexes between compound 2 and α-cyclodrextin, exhibited fluorescent turn-on detection of CN- in 100% aqueous media with the detection limit of 1.3 μM. The turn-on signal is the result of the conversion of the conjugated hemicyanine moiety to a cyano-hemicyanine group via the addition of the cyanide ion. Using paper sensor strips, naked eye detection of cyanide is possible down to 4.59 ng mm-2. Test strips based on compound 2 can act as a convenient and efficient CN- testing kit. © The Royal Society of Chemistry 2015.
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