Polypyrrole-coated electrospun poly(lactic acid) fibrous scaffold: Effects of coating on electrical conductivity and neural cell growth
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Author list: Sudwilai T., Ng J.J., Boonkrai C., Israsena N., Chuangchote S., Supaphol P.
Publisher: Taylor and Francis Inc.
Publication year: 2014
Volume number: 25
Issue number: 12
Start page: 1240
End page: 1252
Number of pages: 13
ISSN: 0920-5063
eISSN: 0920-5063
Languages: English-Great Britain (EN-GB)
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Abstract
Neuronal activities play critical roles in both neurogenesis and neural regeneration. In that sense, electrically conductive and biocompatible biomaterial scaffolds can be applied in various applications of neural tissue engineering. In this study, we fabricated a novel biomaterial for neural tissue engineering applications by coating electrospun poly(lactic acid) (PLA) nanofibers with a conducting polymer, polypyrole (PPy), via admicellar polymerization. Optimal conditions for polymerization and preparation of PPy-coated electrospun PLA nanofibers were obtained by comparing results from scanning electron microscopy, X-ray photoelectron spectrometer, and surface conductivity tests. In vitro cell culture experiments showed that PPy-coated electrospun PLA fibrous scaffold is not toxic. The scaffold could support attachment and migration of neural progenitor cells. Neurons derived from progenitor exhibited long neurite outgrowth under electrical stimulation. Our study concluded that PPy-coated electrospun PLA fibers had a good biocompatibility with neural progenitor cells and may serve as a promising material for controlling progenitor cell behaviors and enhancing neural repair. ฉ 2014 Taylor & Francis.
Keywords
nerve cell, polypyrole, Scaffold
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