Genome-wide association studies of virulent and avirulent Haemophilus parasuis serotype 4 strains
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Author list: Lawrence P.K., Wiener B.L., Kolander-Bremer T., Bey R.F., Stine D.L., Kittichotirat W., Bumgarner R.E.
Publisher: American Society for Microbiology: Open Access Journals
Publication year: 2014
Journal: Genome Announcements (2169-8287)
Volume number: 2
Issue number: 5
ISSN: 2169-8287
Languages: English-Great Britain (EN-GB)
Abstract
Haemophilus parasuis is a normal commensal of the upper respiratory tract of healthy pigs. However, in conjunction with stress and/or viral infections, or in immunocompromised animals, H. parasuis can transform into a pathogen causing Glasser's disease, which is typically characterized by fibrinous polyserositis, polyarthritis, meningitis, and sometimes acute pneumonia and septicemia. H. parasuis serotype 5 is highly virulent and more frequently isolated from respiratory and systemic infection in pigs. Recently Newport Laboratories isolated highly virulent H. parasuis serotype 4 strains from the tissues of diseased pigs. This study was undertaken to identify the genes responsible for H. parasuis serotype 4 virulence. To achieve this objective we performed genome-wide association studies (GWAS) across two virulent and three avirulent H. parasuis serotype 4 strains. ฉ 2014 Lawrence et al.
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