Recent applications of microchip electrophoresis to biomedical analysis
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Publication Details
Author list: Nuchtavorn N., Suntornsuk W., Lunte S.M., Suntornsuk L.
Publisher: Elsevier
Publication year: 2015
Journal: Journal of Pharmaceutical and Biomedical Analysis (0731-7085)
Volume number: 113
Start page: 72
End page: 96
Number of pages: 25
ISSN: 0731-7085
eISSN: 1873-264X
Languages: English-Great Britain (EN-GB)
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Abstract
Many separation methods have been developed for biomedical analysis, including chromatographic (. e.g. high performance liquid chromatography (HPLC) and gas chromatography (GC)) and electrophoretic methods (. e.g. gel electrophoresis and capillary electrophoresis (CE)). Among these techniques, CE provides advantages in terms of high separation efficiency, simplicity, low sample and solvent volume consumption, short analysis time and applicability to a wide range of biomedically important substances. Microchip electrophoresis (ME) is a miniaturized platform of CE and is now considered as a simpler and more convenient alternative, which has demonstrated potential in analytical chemistry. High-throughput, cost-effective and portable analysis systems can be developed using ME. The current review describes different separation modes and detectors that have been employed in ME to analyze various classes of biomedical analytes (. e.g. pharmaceuticals and related substances, nucleic acids, amino acids, peptides, proteins, antibodies and antigens, carbohydrates, cells, cell components and lysates). Recent applications (during 2010-2014) in these areas are presented in tables and some significant findings are highlighted. ฉ 2015 Elsevier B.V..
Keywords
Biomedical analysis, Capillary electrophoresis, Microchip electrophoresis
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