Automation for fabrication of functional tissues by stacking cell sheet

Conference proceedings article

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Publication Details

Author list: Leangarun T., Chumroenrattanakorn P., Koolpirak D., Pasuwat K.

Publisher: Hindawi

Publication year: 2016

ISBN: 9781467380164

ISSN: 0146-9428

eISSN: 1745-4557

URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84988878620&doi=10.1109%2fELINFOCOM.2016.7563001&partnerID=40&md5=5b532cb50c5d708bbb723efe1b890979

Languages: English-Great Britain (EN-GB)

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Abstract

Cell sheet has been applied in regenerative medicine by growing tissues and then implanting them when the body cannot heal itself. Manufacturing of cell sheet requires stacking process of monolayer cell sheet to form multi-layer tissue. The aim of study was to offer automation system for fabrication of functional tissues by stacking cell sheet. Pushing down force, position movement, and responsive temperature were studied. An automation system was designed to handle with 12 mm in diameter and 50 μm thickness of cell sheets. Each cell sheet was attached by thermo responsive surface up to maximum 6-layer. The results showed that stack cell sheets could be constructed, strained by hematoxylin and eosin, and investigated by microscope. © 2016 IEEE.

Keywords

automation system, stacking cell sheet, thermo responsive surface, tissue engineering