Classification of acute leukemia using CD markers

Conference proceedings article

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Publication Details

Author list: Laosai J., Chamnongthai K.

Publisher: Hindawi

Publication year: 2016

Start page: 253

End page: 256

Number of pages: 4

ISBN: 9781467381376

ISSN: 0146-9428

eISSN: 1745-4557

URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84966480030&doi=10.1109%2fKST.2016.7440535&partnerID=40&md5=7d701278cd73ca5b3198393b937b0f64

Languages: English-Great Britain (EN-GB)

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Abstract

This paper presents characteristics of morphology, immunophenotype, molecular and cytogenetic of bone marrow samples were analyzed. Leukemia is divided into two categories which are acute leukemia and chronic leukemia and other types. Our work focuses on classification of Foil of Bretagne (Lymphoid) and Almeida Lloyd (Myeloid). The features are extracted from the segmented images and classified using the Support Vector Machine (SVM). The method has been evaluated using a set of 200 images with 100 abnormal samples and 100 normal samples obtained. The classification proposed 3 subtypes of ALL and 8 subtypes of AML that are characterized by unique morphologic, immunologic, and cytogenetic features Immunologic (MIC group) markers cluster of differentiation (CD). The computer simulations show that the proposed system robustly segments and classifies Acute Myelogenous Leukemia based on complete microscopic blood images. We have obtained accuracy 93.89 %. ฉ 2016 IEEE.

Keywords

cluster of differentiation (CD), flow cytometry, immunophenotyping, Morphologic immunologic cytogenetic (MIC)