Highly selective detection of Cu2+ based on a thiosemicarbazone triphenylacetylene fluorophore
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Publication Details
Author list: Boontom S., Boonkitpatarakul K., Sukwattanasinitt M., Niamnont N.
Publisher: Elsevier
Publication year: 2017
Journal: Tetrahedron (0040-4020)
Volume number: 73
Issue number: 17
Start page: 2483
End page: 2487
Number of pages: 5
ISSN: 0040-4020
eISSN: 1464-5416
Languages: English-Great Britain (EN-GB)
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Abstract
A novel thiosemicarbazone fluorophore (3) was successfully synthesized in 3 steps via Sonogashira coupling and Knoevenagel condensation using baker's yeast (Saccharomyces cerevisiae) as a biocatalyst. Compound 3 contains triphenylacetylene, which acts as a fluorophore, and thiosemicarbazone, which acts as a copper probe. Compound 3 exhibited highly selective detection of Cu2+ ions based on photoinduced electron transfer (PET) in 10 mM HEPES buffer pH 7.4/propylene glycol (70% (v/v)). A linear relationship was observed for Cu2+ concentrations between 0.1 nM and 10 μM, and the detection limit of the method was 0.14 nM. Additionally, 3 was utilized to detect Cu2+ in wastewater with satisfactory results, which highlighted its potential for real sample applications. © 2017 Elsevier Ltd
Keywords
Baker's yeast, Copper(II), Fluorescent probe, Thiosemicarbazone
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