Hybrid transdermal drug delivery patch made from poly(p-phenylene vinylene)/natural rubber latex and controlled by an electric field

Journal article

Authors/Editors

NOPHAWAN PARADEE

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Publication Details

Author list: Niamlang S., Paradee N., Sirivat A.

Publisher: Wiley

Publication year: 2018

Journal: Polymer International (0959-8103)

Volume number: 67

Issue number: 6

Start page: 747

End page: 754

Number of pages: 8

ISSN: 0959-8103

eISSN: 1097-0126

URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85045281768&doi=10.1002%2fpi.5566&partnerID=40&md5=de02bd54bff95b496dff0c30fedb5e0f

Languages: English-Great Britain (EN-GB)

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Abstract

A flexible, natural rubber (NR) patch was developed for electrically controllable transdermal drug delivery. NR latex was crosslinked at various crosslinking ratios under the UV curing method. Ibuprofen (Ibu) was the model drug and was used as the dopant for poly(p-phenylene vinylene) (PPV) acting as the drug encapsulating host. For the pristine Ibu-loaded NR patch, the amount of Ibu permeation increased with decreasing crosslink density and increasing electrical potential. For the Ibu-doped PPV/NR patch, the amount of Ibu release−permeation also increased with increasing electrical potential and was higher than that of the pristine NR matrices. Without an applied electric field, the drug remained attached to the PPV during an initial period of 6 h. Under an applied electric field, the oxidation state of the conductive polymer was altered, the iontophoretic effect, pore formation in the NR matrix, expansion of the pore size in hair follicles and PPV chain expansion combined to increase the Ibu release−permeation amount. Thus, the flexible PPV/NR transdermal drug delivery patch was demonstrated to be effective in drug release−permeation based on the strength of the electrical potential, the crosslinking density and the presence of PPV as the encapsulation host. © 2018 Society of Chemical Industry. © 2018 Society of Chemical Industry

Keywords

drug permeation, ibuprofen, iontophoretic, poly(p-phenylene vinylene)