Entropy generation on MHD peristaltic flow of Cu-water nanofluid with slip conditions
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Publication Details
Author list: Ali A., Shah Z., Mumraiz S., Kumam P., Awais M.
Publisher: Academic Press Inc.
Publication year: 2019
Volume number: 48
Issue number: 8
Start page: 4301
End page: 4319
Number of pages: 19
ISSN: 0045-2068
eISSN: 0045-2068
Languages: English-Great Britain (EN-GB)
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Abstract
Racemic resolution of (+/−)-MAD28, a representative caged xanthone, was accomplished using (1S, 4R)-(−)-camphanic chloride as the chiral agent. Selective crystallization of the resulting diastereomers in acetonitrile produced, after hydrolysis, the pure enantiomers. Screening of racemic MAD28 and both enantiomers across a broad spectrum of breast cancer cell lines revealed that they: (a) are equipotent in each of the breast cancer subtypes examined; and (b) exhibit a higher degree of cytotoxicity against breast cancer cell lines of basal-like subtype and triple negative receptor status. The results support the notion that MAD28 and related caged xanthones are promising drug leads against chemoresistant and metastatic cancers. © 2019 Elsevier Inc.
Keywords
breast cancer, Gambogic acid, Garcinia, Synthetic methods
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