Controlled Release of Dual Antibacterial Drug from Composite Hydrogels

Conference proceedings article

ผู้เขียน/บรรณาธิการ

กลุ่มสาขาการวิจัยเชิงกลยุทธ์

ไม่พบข้อมูลที่เกี่ยวข้อง

รายละเอียดสำหรับงานพิมพ์

รายชื่อผู้แต่ง: Pholpabu P., Somharnwong P., Huaybun N., Cherdbaramee C., Boonpasart V., Komchum L., Phuengsap A.

ผู้เผยแพร่: Hindawi

ปีที่เผยแพร่ (ค.ศ.): 2019

ISBN: 9781728137520

นอก: 0146-9428

eISSN: 1745-4557

URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080093338&doi=10.1109%2fBMEiCON47515.2019.8990291&partnerID=40&md5=be436abc8a38c9e6f6b33ead4ecee4a9

ภาษา: English-Great Britain (EN-GB)

ดูบนเว็บไซต์ของสำนักพิมพ์

บทคัดย่อ

Hydrogels with a controlled release of dual antibacterial drug have been developed to effectively prevent bacterial infections for biomedical applications. The synergistic dual drug aims to fight against drug resistant bacteria, which become more commonly found nowadays. In this study, we fabricated composite hydrogels using calcium carbonate microspheres as drug carriers to load a combination of tetracycline and ampicillin into the matrices for controlled drug release. The composite hydrogels were prepared using three different molar ratios between polymers and crosslinkers to investigate the effect of crosslink density on the physical properties and drug release. The drug release profiles were quantitatively analyzed to compare diffusivity and release mechanism. The results revealed that the crosslinker molar ratio influenced not only the physical properties, but also the drug release rate and mechanism. The different release characteristics of the drugs also suggested chemical interactions between the calcium carbonate microspheres and the small molecules. Such insight could assist designing of composite hydrogels for controlled dual drug release in biomedical applications. ฉ 2019 IEEE.

คำสำคัญ

Composite hydrogel, dual antibacterial drug, microsphere