Scheduling Complexity of an Automated Cell Manufacturing Process
Conference proceedings article
ผู้เขียน/บรรณาธิการ
กลุ่มสาขาการวิจัยเชิงกลยุทธ์
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รายละเอียดสำหรับงานพิมพ์
รายชื่อผู้แต่ง: Kaowtain J., Ku H.-M., Pasuwat K.
ผู้เผยแพร่: IOP Publishing
ปีที่เผยแพร่ (ค.ศ.): 2019
Volume number: 1284
Issue number: 1
นอก: 1742-6588
eISSN: 1742-6596
ภาษา: English-Great Britain (EN-GB)
บทคัดย่อ
Osteoarthritis is currently the most prevalent chronic joint disease and is expected to increase continually due to aging population and obesity epidemic. Many methods exist to treat this disease but the most promising one is cell-based therapy which uses chondrocyte cells. Chondrocyte cells are cultivated in an automated cell manufacturing system (ACMS). However, ACMS suffers from long idle time caused by incubation times required to cultivate cells in different samples in different incubators. But before optimization can be used to find an optimal schedule, the complexity of the ACMS scheduling problem is established. Parallel operation of the ACMS was able to process a maximum of 26 samples in a year, while sequential operation yielded only 14. Moreover, if we produce more sample in a year the number of different schedules will increase. Then, the problem has more complicated. ฉ 2019 Published under licence by IOP Publishing Ltd.
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