Electrospun Gelatin Fiber Mats Mixed With C.carandas Extract and its Enhanced Stability and Bioactivity

บทความในวารสาร

ผู้เขียน/บรรณาธิการ

กลุ่มสาขาการวิจัยเชิงกลยุทธ์

รายละเอียดสำหรับงานพิมพ์

รายชื่อผู้แต่ง: Rongthong W., Niamnont N., Srisuwannaket C., Paradee N., Mingvanish W.

ผู้เผยแพร่: Elsevier

ปีที่เผยแพร่ (ค.ศ.): 2021

Volume number: 110

Issue number: ุ6

หน้าแรก: 2405

หน้าสุดท้าย: 2415

จำนวนหน้า: 11

นอก: 0022-3549

eISSN: 1520-6017

URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099608991&doi=10.1016%2fj.xphs.2020.12.031&partnerID=40&md5=defd1548386d55cea91620363b3e80d0

ภาษา: English-Great Britain (EN-GB)

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บทคัดย่อ

Crude C. carandas fruits ethanol extract (CCE) constituents important bioactive compounds such as phenolics, flavonoids, and vitamin C. Its biological activities include anti-inflammatory, antioxidant, antibacterial, etc. The present work was carried out to study the optimal conditions for fabricating electrospun gelatin fiber mats (GFM) loaded with CCE (CCE-GFM) and to evaluate the release capacity and stability of these bioactive compounds loaded into GFM. The optimal conditions for electrospinning GFM were the electrospinning 30% (w/v) gelatin solution prepared in 25% (v/v) ethanol solution containing 30% (v/v) acetic acid, under the fixed electrostatic field strength of 20 kV and at a distance between noodle tip and ground of 15 cm. The feed rate of an electrospinning solution was 1.5 mL/h. The electrospun gelatin fibers were smooth and continuous under the optimized electrospinning conditions, with an average diameter of 235.69 ± 10.45 nm. Additionally, at the loading of 15% (w/w) CCE in GFM, CCE-GFM exhibited the highest DPPH radical scavenging activity with 88.22 ± 2.62% and the highest tyrosinase inhibitory activity with 38.17 ± 1.86%. Compared with free CCE, CCE-GFM was more thermally stable upon the heating and cooling cycle testing. CCE-GFM had the percent reductions in total contents of phenolics, flavonoids and vitamin C togethering with the percent reductions of DPPH scavenging and anti-tyrosinase activities slower than pure CCE had. Furthermore, the drug release efficiency from CCE-GFM of 15% (w/w) CCE loading that was tested using modified Franz diffusion cell in an acetate buffer solution of pH 5.5 was 30%. CCE-GFM has shown the potential to utilize a facial mask sheet containing CCE valuable in high antioxidant activity for cosmetic applications. © 2021 American Pharmacists Association®

คำสำคัญ

bioactivity, C.carandas, Fiber mats