A new diterpenoid from the leaves of Phyllanthus acidus

Journal article


Authors/Editors


Strategic Research Themes


Publication Details

Author listDuong T.-H., Nguyen T.T., Phan C.-T.D., Nguyen V.-D., Nguyen H.-C., Dao T.-B.-N., Mai D.-T., Niamnont N., Tran T.-N.-M., Sichaem J.

PublisherTaylor and Francis Group

Publication year2022

Volume number36

Issue number2

Start page539

End page545

Number of pages7

ISSN1478-6419

eISSN1478-6427

URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85087815231&doi=10.1080%2f14786419.2020.1789980&partnerID=40&md5=0ce252fd54b623556731fe0d93723cfc

LanguagesEnglish-Great Britain (EN-GB)


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Abstract

A new diterpenoid, phyllane C (1), along with three known compounds, ovoideal E (2), spruceanol (3), and fluacinoid B (4) were isolated from the leaves of Phyllanthus acidus growing in Thailand. The structures were determined by analysis of their MS and NMR data as well as by comparison with literature values. DFT-NMR chemical shift calculations and subsequent DP4/DP4+ probability methods were applied to define the relative configuration of 1. Compound 3 showed a weak cytotoxicity against K562 cell line (IC50 41.9 ± 2.31 µg/mL). © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group.


Keywords

diterpenoidphyllane C


Last updated on 2023-26-09 at 07:36