A new diterpenoid from the leaves of Phyllanthus acidus
Journal article
Authors/Editors
Strategic Research Themes
Publication Details
Author list: Duong T.-H., Nguyen T.T., Phan C.-T.D., Nguyen V.-D., Nguyen H.-C., Dao T.-B.-N., Mai D.-T., Niamnont N., Tran T.-N.-M., Sichaem J.
Publisher: Taylor and Francis Group
Publication year: 2022
Volume number: 36
Issue number: 2
Start page: 539
End page: 545
Number of pages: 7
ISSN: 1478-6419
eISSN: 1478-6427
Languages: English-Great Britain (EN-GB)
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Abstract
A new diterpenoid, phyllane C (1), along with three known compounds, ovoideal E (2), spruceanol (3), and fluacinoid B (4) were isolated from the leaves of Phyllanthus acidus growing in Thailand. The structures were determined by analysis of their MS and NMR data as well as by comparison with literature values. DFT-NMR chemical shift calculations and subsequent DP4/DP4+ probability methods were applied to define the relative configuration of 1. Compound 3 showed a weak cytotoxicity against K562 cell line (IC50 41.9 ± 2.31 µg/mL). © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group.
Keywords
diterpenoid, phyllane C