Isolation of 3-(Hydroxyacetyl)indole and Indole-3-carboxylic acid from Red Alga Halymenia durvillei : Their Anti-lung Cancer Cell and in vivo Anti-aging Activity

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Author list: Manohong P., Sornkaew N., Meemon K., Chumphoochai K., Sobhon P., Tamtin M., Sichaem J., Mingvanish W., Srisuwannaket C., Mingvanish W., Niamnont N.

Publisher: Chemic Publishing Company

Publication year: 2021

Journal: Asian Journal of Chemistry (0970-7077)

Volume number: 33

Issue number: 4

Start page: 775

End page: 780

Number of pages: 6

ISSN: 0970-7077

URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103642906&doi=10.14233%2fajchem.2021.23051&partnerID=40&md5=db7b5b3de9ec49262057137de18eba7e

Languages: English-Great Britain (EN-GB)

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Abstract

This study aimed to evaluate the bioactivity and phytochemical investigation in red algae Halymenia durvillei. The polarity based solvent partition (hexane, ethyl acetate, butanol and water) of H. durvillei ethanolic crude were used for characterization. The present results of the ethyl acetate extract of red alga H. durvillei generated a 3-(hydroxyacetyl)indole (1), indole-3-carboxylic acid (2) as well as two fatty acids viz. palmitic acid (3) and α-linoleic acid (4). The viability against lung cancer cells of compounds 1 and 2 showed moderate activities against the A549 cell line with inhibition percentages of 12.97% and 25.81%, respectively. Analysis of the dose response of C. elegans anti-aging assay indicated that the survival rate of compound 1 was 12.62% while it was 11.04% for compound 2. Furthermore, H. durvillei isolation was used as an antioxidant, anti-cancer cell and anti-aging resource. © 2021 Chemical Publishing Co.. All rights reserved.

Keywords

3-(Hydroxyacetyl)indole, Anti-aging activity, Anti-cancer cell, Halymenia durvillei