Synthesis and cytotoxic evaluation of usnic acid benzylidene derivatives as potential anticancer agents

Journal article

Authors/Editors

NAKORN NIAMNONT

Strategic Research Themes

Publication Details

Author list: Huynh T.T.L., Nguyen T.P., Niamnont N., Mac D.H., Pham D.D., Chavasiri W., Nguyen K.P.P., Duong T.H., Nguyen V.K., Sichaem J., Nguyen H.H., Nguyen X.H.

Publisher: Taylor and Francis Group

Publication year: 2021

Journal: Natural Product Research (1478-6419)

Volume number: 35

Issue number: 7

Start page: 1097

End page: 1106

Number of pages: 10

ISSN: 1478-6419

eISSN: 1478-6427

URL: https://www.tandfonline.com/doi/full/10.1080/14786419.2019.1639176

Languages: English-United States (EN-US)

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Abstract

A series of usnic acid benzylidene derivatives (groups I-V) were designed, synthesized and evaluated for their anticancer activity in the search for potentially new anticancer agents. Compounds 1a, 5b, 2b, 2e and 2f exhibited the most potent cytotoxcity against K562 cell line with IC₅₀ values of 10.0 ± 3.6, 5.6 ± 0.4, 8.8 ± 1.0, 4.5 ± 0.1 and 8.4 ± 0.4 μM, respectively. It is noteworthy that compound 2e displayed potent cytotoxicity against K562 cells without any cytotoxic effect on HEK293 normal cell line.

Keywords

aldol condensation, benzylidene derivative, cytotoxicity, Usnic acid