A new labdane-type diterpenoid from the leaves of Vitex negundo L.

Journal article

Authors/Editors

NAKORN NIAMNONT

Strategic Research Themes

Publication Details

Author list: Mac D.H., Mai D.T., Nguyen H.C., Tran T.N.M., Pham N.K.T., Nguyen H.H., Niamnont N., Duong T.H., Sichaem J., Nguyen H.H., Nguyen V.H.

Publisher: Taylor and Francis Group

Publication year: 2021

Volume number: 35

Issue number: 14

Start page: 2329

End page: 2334

Number of pages: 6

ISSN: 1478-6419

eISSN: 1478-6427

URL: https://www.tandfonline.com/doi/full/10.1080/14786419.2019.1672687

Languages: English-United States (EN-US)

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Abstract

A new labdane-type diterpenoid, named vitexnegundin (1), along with seven known compounds, including vitexilactone (2), vitetrifolin D (3), 13-hydroxy-5(10),14-halimadien-6-one (4), (rel 3S,5S,8R,9R,10S)- 3,9-dihydroxy-13(14)-labden-16,15-olide (5), artemetin (6), vitexcarpin (7) and penduletin (8), were isolated from the leaves of Vitex negundo L. Their structures were elucidated by using spectroscopic methods, X-ray crystallographic analysis and comparison with those reported in the literature. Moreover, all isolated compounds 1–8 were evaluated for their antimicrobial activity against ESBL-producing Escherichia coli strain and methicillin-resistant Staphylococcus aureus.

Keywords

Antimicrobial activity, labdane-type diterpenoid, vitexnegundin, Vitex negundoL