Hexane extract of seaweed caulerpa lentillifera inhibits cell proliferation and induces apoptosis of human glioblastoma cells
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Publication Details
Author list: Tamtin M., Sangpairoj K., Tanawoot V., Vivithanaporn P., Siangcham T., Meemon K., Niamnont N., Sobhon P.
Publication year: 2021
Volume number: 26
Issue number: 2
Start page: 128
End page: 137
Number of pages: 10
ISSN: 2586-9000
URL: https://ph02.tci-thaijo.org/index.php/SciTechAsia/article/view/219342
Languages: English-United States (EN-US)
Abstract
neoplastic drugs. Marine seaweeds possess valuable bioactive compounds for disease prevention and therapy, including for a number of cancers. Caulerpa lentillifera is a tropical marine seaweed containing various minerals and bioactive ingredients. This study demonstrated the activity of C. lentillifera hexane extract (CLHE) against A172 human glioblastoma cells. The extract exerted growth- inhibitory effects by inhibiting cell proliferation and inducing apoptosis. CLHE also induced ROS accumulation and altered mitochondrial membrane potential in A172 cells. Taken together, CLHE might be a potential anticancer agent for use against glioblastoma
Keywords
Apoptosis, Caulerpa lentillifera, Glioblastoma, Proliferation, Seaweed
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