Determination of sibutramine compound in slimming supplements using distance-based paper devices

Sibutramine was adulterating in slimming supplementary used for lost weight in recent years. We developed microfluidic paper-based analytical devices (μPADs) for the determination of sibutramine by the oxidation reaction of the potassium permanganate and the etching reaction of AgNPs with the permanganate remaining. Potassium permanganate remaining in an alkaline medium can be reacted with AgNPs observed a change of pink to a colorless band length by the ruler. Under the optimal conditions, the calibration curve between the colorless band and sibutramine concentration was in the range of 6.3-158 μmol/L, and the detection limit was found to be 6.3 μmol/L. Our proposed devices can be applied to detect sibutramine in real samples and are instrument-free, portable, and cost-efficiency. For the validation method, our results were no significant distinction in accuracy and precision.