Synthesis of Solid Lipid Nanoparticles Containing CoenzymeQ10 and Vitamin E through Hot Homogenization Process

The aim of present work was to develop a new formulation of Solid Lipid Nanoparticles (SLNs) containing Coenzyme Q10 (CoQ10) and Vitamin E (VitE) for transdermal drug delivery application using hot homogenization process. Three different conditions without drug loading were modified for optimization. The optimum condition was further used to prepare VitE-loaded SLNs and CoQ10&VitE-loaded SLNs. All drug-free and drug-loaded nanoparticles were in a diameter size range of 100 to 200 nm. The mean diameter of drug-free SLNs, SLNs containing VitE, SLNs containing CoQ10&VitE were 135 ± 39, 141 ± 37 and 162 ± 46 nm, respectively. Monodispersed SLNs were successful prepared with Polydispersity Index (PDI) value (below 0.5). Zeta potential value was around 40 mV for all prepared particles providing a good physical stability. Except that of CoQ10&VitE-loaded particles, their zeta potential was around -60 mV. By UV-vis spectrophotometer, the encapsulation efficiency of VitE-loaded and CoQ10&VitE-loaded SLNs were nearly 100%. XRD analysis results showed amorphousness (broad peak) of the prepared nanoparticles (NPs).