Cytotoxic Constituents of the Fruits of Garcinia schomburgkiana

Journal article

Authors/Editors

NAKORN NIAMNONT

Strategic Research Themes

Smart Healthcare (Strategic Research Themes)

Publication Details

Author list: Lien Thi My Do, Van-Kieu Nguyen, Nguyen Thi Le Thuy, Nakorn Niamnont, Suekanya Jarupinthusophon, Kewalin Inthanon, Jirapast Sichaem

Publisher: Springer

Publication year: 2024

Volume number: 60

Issue number: 3

Start page: 492

End page: 495

Number of pages: 4

ISSN: 0009-3130

eISSN: 1573-8388

URL: https://link.springer.com/article/10.1007/s10600-024-04359-7

Languages: English-United States (EN-US)

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Abstract

All isolated compounds were assessed for their cytotoxicity against the A549, DU145, and MCF-7 cell lines using the MTT method [13]. After a 24-hour incubation period, compound 13 displayed significant cytotoxicity against A549 cancer cells, with an IC50 value of 310 μM (cisplatin, IC50 = 373 μM). Subsequently, after a 72-h incubation period, compound 13 exhibited the highest cytotoxicity towards A549 cancer cells, with an IC50 value of 132 μM. On the other hand, compound 1 showed the highest cytotoxicity against DU145 cancer cells, with an IC50 value of 105 μM.

Keywords

G. schomburgkiana fruits