CFD modeling of particle deposition in human airways: Effect of inhalation rate, body temperature, and relative humidity

บทความในวารสาร

ผู้เขียน/บรรณาธิการ

กลุ่มสาขาการวิจัยเชิงกลยุทธ์

รายละเอียดสำหรับงานพิมพ์

รายชื่อผู้แต่ง: Adnan, M.; Kampeewichean, C.; Tanprasert, S.; Korkerd, K.; Piumsomboon, P.; Tipratchadaporn, S.; Chalermsinsuwan, B.; Piemjaiswang, R.

ผู้เผยแพร่: Elsevier

ปีที่เผยแพร่ (ค.ศ.): 2026

Volume number: 108

หน้าแรก: 99

หน้าสุดท้าย: 112

จำนวนหน้า: 14

นอก: 1674-2001

eISSN: 2210-4291

URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-105023710674&doi=10.1016%2Fj.partic.2025.11.001&partnerID=40&md5=a4c1ac3c60326213f7af983e145d5904

ภาษา: English-Great Britain (EN-GB)

ดูบนเว็บไซต์ของสำนักพิมพ์

บทคัดย่อ

This study examines local particle deposition in an idealized Weibel tracheobronchial model up to six generations (G0–G6). The Discrete Phase Model (DPM) was employed to simulate airflow and particle motion. This study aimed to explore the combined effects of transient airflow patterns and environmental conditions (body temperature and relative humidity). These environmental factors can alter airflow properties, which in turn affect particle transport and deposition in human airways. Results of this study show that airflow rate and body temperature have a strong influence on deposition and particle escape, with airflow rate being the dominant factor. Deposition increases with airflow rate, while body temperature reduces it. Moreover, particle escape decreases as more particles attach to the fluid phase. The highest deposition is predicted in G1. Furthermore, at the outlet, velocity is observed to be considerably higher than at the inlet, and particle trajectories remain asymmetrical despite the airway’s symmetrical geometry. Although this work is based on an idealized Weibel model that cannot fully replicate the patient-specific airways, the findings of this study under realistic environmental conditions provide valuable insights for fundamental research on particle behavior and deposition in the human respiratory system. © 2025 Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences.

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