Synthesis and cytotoxic evaluation of usnic acid benzylidene derivatives as potential anticancer agents

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Author list: Nguyen V.-K., Sichaem J., Nguyen H.-H., Nguyen X.H., Huynh T.-T.-L., Nguyen T.-P., Niamnont N., Mac D.-H., Pham D.-D., Chavasiri W., Nguyen K.-P.-P., Duong T.-H.

Publisher: Taylor and Francis Ltd.

Publication year: 2019

Volume number: 35

Issue number: 7

ISSN: 1478-6419

eISSN: 1478-6419

URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85068922264&doi=10.1080%2f14786419.2019.1639176&partnerID=40&md5=8d6e76ba473b2132d24358d14da6ec9c

Languages: English-Great Britain (EN-GB)

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Abstract

A series of usnic acid benzylidene derivatives (groups I-V) were designed, synthesized and evaluated for their anticancer activity in the search for potentially new anticancer agents. Compounds 1a, 5b, 2b, 2e and 2f exhibited the most potent cytotoxcity against K562 cell line with IC50 values of 10.0 ± 3.6, 5.6 ± 0.4, 8.8 ± 1.0, 4.5 ± 0.1 and 8.4 ± 0.4 μM, respectively. It is noteworthy that compound 2e displayed potent cytotoxicity against K562 cells without any cytotoxic effect on HEK293 normal cell line. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.

Keywords

aldol condensation, benzylidene derivative, Usnic acid