Schomburgkixanthone, a novel bixanthone from the twigs of Garcinia schomburgkiana

Journal article

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Publication Details

Author list: Lien Do T.M., Duong T.-H., Nguyen V.-K., Phuwapraisirisan P., Doungwichitrkul T., Niamnont N., Jarupinthusophon S., Sichaem J.

Publisher: Taylor and Francis Group

Publication year: 2021

Volume number: 35

Issue number: 21

Start page: 3613

End page: 3618

Number of pages: 6

ISSN: 1478-6419

eISSN: 1478-6427

URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078431910&doi=10.1080%2f14786419.2020.1716351&partnerID=40&md5=e46d7423d4caa37873aa1f8acdfcb9b1

Languages: English-Great Britain (EN-GB)

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Abstract

A novel bixanthone, named schomburgkixanthone (1), was isolated from the twigs of Garcinia schomburgkiana, along with six known compounds, griffipavixanthone (2), 4-hydroxyxanthone (3), 2-hydroxyxanthone (4), 1,6-dihydroxyxanthone (5), 1,7-dihydroxyxanthone (6), and 1,3,5-trihydroxyxanthone (7). The structure of 1 was identified by the application of NMR and MS data analyses and comparison with previous reports. Compound 1 showed the most powerful inhibition of rat intestinal α-glucosidase, with IC50 values of 0.79 for maltase and 1.81 mM for sucrase. Compound 2 most strongly inhibited sucrase, with an IC50 value of 4.58 mM. © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group.

Keywords

bixanthone, Garcinia schomburgkiana, Guttiferae, schomburgkixanthone, α-glucosidase inhibition