Identification of highly potent α-glucosidase inhibitors from Garcinia schomburgkiana and molecular docking studies
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Author list: Thi My Lien Do, Nguyen-Minh-An Tran, Thuc-Huy Duong, Preecha Phuwapraisirisan,
Nakorn Niamnont, Suttira Sedlak, Kewalin Inthanon, and Jirapast Sichaem
Publisher: Prince of Songkla University
Publication year: 2021
Journal: Songklanakarin Journal of Science and Technology (SJST) (0125-3395)
Volume number: 43
Issue number: 6
Start page: 1597
End page: 1603
Number of pages: 7
ISSN: 0125-3395
URL: https://rdo.psu.ac.th/sjstweb/Ar-Press/2021Jan/19.pdf
Languages: English-Great Britain (EN-GB)
Abstract
Twenty-two compounds (1-22) were isolated from the stems and twigs of Garcinia schomburgkiana. NMR, IR, UV, and MS were used for structural elucidation, and comparisons were made with previous reports. Compound 1 exhibited the most potent α-glucosidase inhibition (IC50 0.31 ± 0.7 μM), outperforming the positive control (acarbose). Molecular docking results showed that the phenolic hydroxyl groups on the phenyl rings linked with active receptor sites on the protein in 1. By preventing the duplication of DNA sequences, Compound 1 is an excellent inhibitor of the α-glucosidase enzyme, and represents a potential novel class of α-glucosidase inhibitor.
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