Effect of entrapped α-tocopherol on mucoadhesivity and evaluation of the release, degradation, and swelling characteristics of zein-chitosan composite electrospun fibers
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Author list: Wongsasulak S., Pathumban S., Yoovidhya T.
Publisher: Elsevier
Publication year: 2014
Journal: Journal of Food Engineering (0260-8774)
Volume number: 120
Issue number: 1
Start page: 110
End page: 117
Number of pages: 8
ISSN: 0260-8774
Languages: English-Great Britain (EN-GB)
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Abstract
A gastro-mucoadhesive matrix of ultrafine fibers was formed from composite polymers of zein, poly(ethylene oxide), and chitosan at a ratio of 87.5/10/2.5 via electrospinning. Alpha-tocopherol (α-TOC), a hydrophobic compound, was embedded at 20 wt% into the fiber matrix to investigate its effects on fiber morphology and mucoadhesivity. α-TOC release characteristics were examined in simulated gastric fluid (SGF) at pH 1.2 with pepsin and SGF at pH 2 without pepsin at 37 ± 0.5 C. Gastro-mucoadhesivity was tested in porcine gastric mucosa. Fiber morphology was characterized by scanning electron microscopy (SEM). α-TOC did not affect fiber morphology, but significantly enhanced mucoadhesivity (p < 0.05). α-TOC release in SGF at pH 1.2 with pepsin was triggered by erosion, and α-TOC release in SGF at pH 2 without pepsin was triggered by swelling, and driven by diffusion. SEM micrographs revealed that the fibers lost their fibrous structure and later fused, minimizing the fibrous film release surface area. © 2013 Elsevier Ltd. All rights reserved.
Keywords
alpha-tocopherol, Mucoadhesion, Release characteristics
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